Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava
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منابع مشابه
Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9, 11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9, 11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of ...
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Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhib...
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Three marine prostanoids, 1, 2, and 3, were isolated from the extract of the Okinawan soft coral Clavularia viridis. The structures of these compounds were assigned based on the results of spectroscopic analysis. Compound 1 was shown to be preclavulone-A methyl ester, and this is the first isolation of the ester of preclavulone-A as a natural product. Preclavulone-A is proposed to be the key in...
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In the present issue of Circulation, Meiners and his colleagues1 show that local application of a proteasome inhibitor resulted in significant inhibition of intimal hyperplasia in a balloon injury model in rat carotid artery. This report is of interest because it identifies a novel target for the treatment of restenosis and introduces a rapidly developing field in basic science to cardiovascula...
متن کاملThe Ubiquitin and Proteasome Pathway
The ubiquitination and proteasome degradation pathway is a multistep enzymatic cascade in eukaryotes in which ubiquitin is conjugated via a lysine residue at position 48 to target proteins for destruction. Proteins tagged with lysine 48–linked chains of ubiquitin are marked for degradation in the proteasome enzyme complex (Figure 1). Through this pathway, the cell rids itself of excess and misf...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2020
ISSN: 1660-3397
DOI: 10.3390/md18010039